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AJMALINE IN THE MANAGEMENT OF CARDIAC ARRHYTHMIAS

Muhammad Ilyas
Pakistan

INTRODUCTION

Ajmaline* a tertiary indolin base was first isolated, from the Indian plant, rauwolfia serpentina by Dr. Salimuzzaman Siddiquil, and named after Hakim Ajmal Khan, a pioneer of Tib in India, who had extensively used products of rauwolfia as anti-hypertensive and cardiac sedative. Ajmaline is a member of a second group of rauwolfia derivatives which have no sedative, hypnotic or hypotensive effects. It has been found to have potent anti-arrhythmic properties 2,10 and is extremetly successful in the treatment of arrhythmias associated with Wolff-Parkinson-White syndrome 11 -15.

This paper presents our ongoing experience with the drug and summarises the world literature.

CONCLUSION

Ajmaline has now been effectively used for half a century.  The major work emanates from the German centres and most of the literature is in the German language.  It is an effective antiarrhythmic agent and is particularly effective in arrhytmias associated with Woff-Parkinson-White syndrome.